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Amphotericin B synthesis br Concluding Remarks and Future Di
2023-11-04
Concluding Remarks and Future Directions The physiological significance of autophagy in neuronal function is steadily emerging. The studies discussed herein reveal that key neuronal functions, such as neurotransmitter release, pruning of dendritic spines, and behavioural outputs of neural network
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STI571 TUNEL assay Apoptotic DNA fragmentation in cells was
2023-11-04
TUNEL assay. Apoptotic DNA fragmentation in STI571 was measured using a commercially available TUNEL assay kit (Thermo Fisher). Frozen cells were fixed with 10% paraformaldehyde/PBS. Apoptosis was determined by staining the 3′-OH ends of fragmented DNA with biotin-dNTP using DNA I klenow fragment a
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According to the phytochemical screening Lophira procera
2023-11-04
According to the phytochemical screening, Lophira procera is rich in phenolic compounds including total polyphenols, total flavonoids, tannins and proantocianidins. It has been reported that there is a correlation between total polyphenol content and antioxidant activity [29]. The present invention
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Y-27632 Testosterone can be converted into
2023-11-04
Testosterone can be converted into estrogens by aromatase action. Aromatase is encoded by CYP19, belongs to cytochrome P450 superfamily, and synthesizes estradiol (E2) and estrone (E1) from testosterone and androstenedione respectively (Fig. 1). Aromatase is expressed in the ORS of anagen hair folli
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The specific mechanism and neurotoxic A
2023-11-04
The specific mechanism and neurotoxic Aβ epinephrine adrenaline mg are yet to be elucidated, however recent studies have provided significant evidence for the amyloid channel hypothesis. These reports have established that relatively small oligomers ( Conflict of interest Acknowledgements This
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br Mortality and morbidity Alzheimer s disease is
2023-11-04
Mortality and morbidity Alzheimer's disease is officially listed as the sixth-leading cause of death in the United States [208]. It is the fifth-leading cause of death for those age 65 and older [198]. However, it Chlorpromazine HCl may cause even more deaths than official sources recognize. Alz
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br Introduction There are greater than five million American
2023-11-04
Introduction There are greater than five million Americans living with Alzheimer's dementia and more than 35 million people worldwide [1], and without a way to stop or slow the progression, there will be nearly a tripling of individuals affected by 2050 (13.8 million) [1]. The urgency to develop
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br Distribution of OCT in rat brain
2023-11-04
Distribution of OCT3 in rat brain To understand the potential roles of this corticosterone-sensitive monoamine clearance mechanism in the regulation of monoaminergic neurotransmission and behavior, and its potential contribution to corticosteroid actions on behavior, we examined the rostrocaudal
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The indirect effect of corporate taxation as given by the
2023-11-03
The indirect effect of corporate taxation, as given by the second term in Eq. (18), consists of two elements; (i) a standard Remember effect (τ/n2), and (ii) a capital cost effect (rG(1−αt)/(1−t)). With a CRS technology, the cost effect vanishes, whereas with an IRS (a DRS) technology the cost effec
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Fourth non canonical sites may
2023-11-03
Fourth, non-canonical sites may be targeted. Classical benzodiazepines require the presence of a γ subunit for high-affinity binding, which limits their activity to a specific large pool of receptor isoforms, leaving other isoforms unaffected. In particular, δ subunit-containing receptors, as well a
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The current antifungal pipeline contains
2023-11-03
The current antifungal pipeline contains several categories of compounds at different stages of development [1], [9], [10], [96]. In Table 1 we summarize the most promising antifungal molecules that are in preclinical and in clinical development. Several compounds in the pipeline are derivatives of
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Based on the general structure
2023-11-03
Based on the general structure-function principle in biology [[19], [20], [21]], toxic oligomers are expected to have well-defined three-dimensional structures to carry out their pathological functions. A common amyloid toxicity mechanism also suggests that toxic oligomers of different amyloid prote
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A previous study reported that the serotonergic mechanism wa
2023-11-02
A previous study reported that the serotonergic mechanism was involved in the psychological stress-induced alteration in synaptic plasticity in the rat hippocampal CA1 field (Matsumoto et al., 2004). Sumitaka Inoue et al. (Inoue et al., 2014) reported that pretreatment with a 5-HT1A receptor partial
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br Conflict of Interest br Transparency Document br Introduc
2023-11-02
Conflict of Interest Transparency Document Introduction Mitoxantrone (MXT) is an androstenedione chemotherapeutic agent that is used to treat acute nonlymphocytic leukemia, acute lymphoblastic leukemia, prostate cancer, metastatic breast cancer, and non-Hodgkin’s lymphoma [13], [14]. It is
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The enzyme plays an important role in the
2023-11-02
The enzyme plays an important role in the purine metabolism of this parasite. Like other parasitic protozoa, T. gondii is incapable of de novo purine biosynthesis and depends totally on preformed purines salvaged from the host Epothilone B for its purine requirements and survival (Perrotto et al.,
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