• Several reports of single cases of MG

  2023-05-06

  

  Several reports of single cases of MG patients treated with Rituximab have claimed a favourable response (Baek et al., 2007, Gajra et al., 2004, Hain et al., 2006, Thakre et al., 2007, Wylam et al., 2003, Zaja et al., 2000). We report our experience with Rituximab in 6 patients with severe MG, 3 pa

• NG25 Until now there are no

  2023-05-06

  

  Until now, there are no report regarding the relationship of CD21 and MG. In the present study, we aimed to characterize the AchR specified NG25 and investigated the role of CD21 in immunopathogenesis of MG. We utilized the Allophycocyanin (APC)-conjugated AchR to measure the frequencies of AchR spe

• Our study like that of Zill et al included

  2023-05-06

  

  Our study, like that of Zill et al. (2012) included European Caucasians, although their population was much smaller (n=162) and more heterogeneous (19–72years). Further, potential confounding or effect modification by other health, lifestyle or genetic factors was not considered. These differences m

• Conclusion Twenty compounds with dinitrobenzoate

  2023-05-06

  

  Conclusion Twenty compounds with 3,5-dinitrobenzoate scaffold were synthesized and evaluated using cell-free and HWB assays for their 5-LOX inhibition activities. Compared to the parent compound, six compounds show significantly increased enzyme inhibition activities. The best compound, 3-tolyl 3,5

• In the nineties we knew that baclofen was

  2023-05-06

  

  In the nineties we knew that (-)baclofen was the stereo-selective ligand for the GABAB receptor which had been recognised by Norman Bowery as a receptor for GABA, which was different from the GABAA receptor (Hill and Bowery, 1981). GABAB receptor antagonists were also synthesised and made available

• br Eprosartan The AT R antagonist

  2023-05-04

  

  Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential 3845 and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cerebrovascular events, independe

• Although mature fibrils formed from A aggregates

  2023-05-03

  

  Although mature fibrils formed from Aβ 22 9 have long been thought to be the main neurodegenerative agents in AD, recent evidence suggests that soluble multimers of these pathogenic proteins, referred to here as “oligomers,” may initiate the synaptic and neuronal dysfunction associated with AD and

• SAG Since all the above vascular and

  2023-05-02

  

  Since all the above vascular and glomerular effects contribute to blood pressure regulation, it is expected for 12/15-LOX pathway to play a role in pathogenesis of hypertension (Fig. 6). Indeed, there is evidence for alterations of the 12- and 15LOX enzymes and metabolites both in humans with essent

• SAG Since all the above vascular and

  2023-05-02

  

  Since all the above vascular and glomerular effects contribute to blood pressure regulation, it is expected for 12/15-LOX pathway to play a role in pathogenesis of hypertension (Fig. 6). Indeed, there is evidence for alterations of the 12- and 15LOX enzymes and metabolites both in humans with essent

• ADOR immunoreactivity was high in parasympathetically innerv

  2023-04-26

  

  ADOR immunoreactivity was high in parasympathetically-innervated smooth muscle, namely the iris sphincter muscle and the ciliary muscle. No ADOR immunoreactivity was noted in the sympathetically-innervated iris dilator muscle. Immunoreactivity against all four ADORs was noted in the ciliary epitheli

• Altogether the situations described above clearly impede the

  2023-04-26

  

  Altogether, the situations described above clearly impede the critical steps of drug discovery and development and the scientific process in general [14]. In conclusion, it is the opinion of these authors that many exciting lines of drug discovery (which includes those devoted to nAChR ligands) have

• Although effects of low concentrations of

  2023-04-26

  

  Although effects of low concentrations of agonist were not as thoroughly documented for heteromeric receptors such as the major Carmustine α4β2 nAChR, a similar mechanism of action was described to explain the potentiation of these receptors with low concentrations of acetylcholine-esterase-inhibit

• SGC707 sale We also show that in both ATM proficient

  2023-04-25

  

  We also show that in both ATM proficient and deficient/mutant SGC707 sale the activation of ATR signaling is DSB complexity-dependent (Figs. 1, 4A, C and E, 6A and B). Wang et al. have also reported that the effects of ATR and CHK1 on radiosensitivity are independent of the NHEJ repair pathway [41]

• There are profound differences between acute and

  2023-04-25

  

  There are profound differences between acute and chronic pain when dramatic changes occur in peripheral nociceptors and central nociceptive pathways and the pain system is sensitised thereby leading to exaggerated responses to noxious stimuli (hyperalgesia) and responses to non-noxious stimuli (allo

• br Abbreviations br Acknowledgements This work

  2023-04-25

  

  Abbreviations Acknowledgements This work was supported by grants from the National Institutes of Health (R01GM114168) and the Office of Naval Research (N000141210773) awarded to J.C·H and National Cancer Institute (5P30CA16059) Cancer Center Support Grant in support of Massey Cancer Center Pro

14969 records 314/998 page Previous Next First page 上5页 311312313314315 下5页 Last page