• Oxidation of N hydroxyguanidine by DbH was studied by HPLC

  2019-08-13

  

  Oxidation of N-hydroxyguanidine 1 by DbH was studied by HPLC and some oxidation products for 1 could be characterized. The compounds generally observed with iron-containing systems are 4-methoxyphenylurea 11 and 4-methoxyphenylcyanamide 12 (Fig. 2). Oxidation of N-(4-chlorophenyl)-N′-hydroxyguanidin

• Our previous work has demonstrated that

  2019-08-13

  

  Our previous work has demonstrated that two glutamate residues (Glu-305 and Glu-331 in murine and human TPP II) in the active site are important for exopeptidase activity in mTPP II [17]. At least one of these, Glu-331, seems to form a salt bridge to the N-terminal amino group of the substrate, posi

• br Introduction Abdominal aortic aneurysm AAA is a daily con

  2019-08-13

  

  Introduction Abdominal aortic aneurysm (AAA) is a daily concern in vascular surgery, as successful treatment is exclusively achieved by open or endovascular repair. Its prevalence is 2–11% among male smokers, and rupture the major complication, is associated with unacceptably high morbidity and m

• Natural progestogens play an important role

  2019-08-13

  

  Natural progestogens play an important role in the stimulation of oocyte growth and maturation as well as in spermatogenesis and sperm maturation, and they act as sex pheromones in teleost fish (Kime, 1990, Kobayashi et al., 2002, Nagahama and Yamashita, 2008, Scott et al., 2010). A complex series o

• br Introduction br Sphingolipid metabolism Sphingolipids are

  2019-08-13

  

  Introduction Sphingolipid metabolism Sphingolipids, are fundamental constituents of all eukaryotic membranes and their metabolism is carried out by a broad array of anabolic and BYL719 with ceramide as their hub (for a review, (Hannun and Obeid, 2018)). Ceramide can be formed by multiple path

• For the first time the V

  2019-08-13

  

  For the first time, the V. carinata transcriptome was analyzed and its transcript coding sequences comprehensively characterized. The non-redundant contigs encoding putative CysPs were identified and their TNF-alpha, recombinant rat protein patterns in different tissues were investigated. Our study

• Unlike CRM exportins Cse and Xpot lack a C

  2019-08-13

  

  Unlike CRM1, exportins Cse1 and Xpot lack a C-extension and instead rely primarily on changes in HEAT-repeat conformation and direct Ran-cargo contacts to ensure low cargo-binding affinity in the cytosol and cooperative assembly of the exportin/Ran/cargo complex in the nucleus (Cook et al., 2005, Co

• Apart from its high affinity

  2019-08-13

  

  Apart from its high affinity, the selection of GW2580 as sb chemical lead in our radiotracer development program was motivated by its exceptional selectivity. The observed profound impact of small structural modifications on the selected panel of four kinases tested prompted us to conduct comprehens

• Mechanistically GW treatment modulated cytokine expression

  2019-08-13

  

  Mechanistically, GW2580 treatment modulated cytokine expression within the kidney. We noted a decrease in the levels of TNF, MCP-1, IL-1β, IL-27, and GM-CSF in GW2580 treated mice. Decreased levels of these proinflammatory cytokines likely contributed to the attenuated proteinuria and improved renal

• Introduction BRs are well known class of

  2019-08-12

  

  Introduction BRs are well known class of steroid phytohormones involved in the regulation of key processes of plant growth and development [1], [2], [3], [4], [5]. A lot of attention is driven to BRs in the last decade because of their undeniable functions in promoting WEHI-539 reactions of plants

• br Results br Discussion Adaptive drug resistance is a

  2019-08-12

  

  Results Discussion Adaptive drug resistance is a major challenge to the clinical success of cancer therapies. Incomplete inhibition of oncogenic signaling allows survival of “drug-tolerant” tumor cells, which persist in that state for variable periods before acquiring additional genetic mutati

• In vitro studies suggest that cPLA does

  2019-08-12

  

  In vitro studies suggest that cPLA2α does not show clear preference for the headgroup present at the sn-3 position, although a slight preference for zwitterionic phospholipids such as PC and PE has recently been pointed out [24]. In this regard, mass spectrometry analyses of glycerophospholipid hydr

• br Acknowledgments br Introduction Hypertensive retinopathy

  2019-08-12

  

  Acknowledgments Introduction Hypertensive retinopathy is a disease of the retinal microvasculature associated with elevated blood pressure (Fraser-Bell et al., 2017). Narrowing of retinal arterioles occurs in the early stage of the disease, and with persistent hypertension further vascular pat

• rucaparib in At the therapeutic level the

  2019-08-12

  

  At the therapeutic level, the logical approach to address the cooperation between FGFR4 and EGFR was the combined inhibition of both receptors. To explore the potential efficacy and specificity of this approach, we tested the effect of FGFR and EGFR inhibitors in monotherapy or in combination in syn

• WES and validation by Sanger sequencing in

  2019-08-12

  

  WES and validation by Sanger sequencing in PNGS-252 revealed an apparent homozygous c.4C>G missense alteration (GenBank: NM_014176.3), resulting in the amino prmt5 inhibitor substitution p.Gln2Glu (Figure 1A). This mutation must be very rare, because this is not listed in the NHLBI Exome Sequencing

14451 records 946/964 page Previous Next First page 上5页 946947948949950 下5页 Last page